Desktop Barcode Printer Battle: Zebra ZD420 Series vs Honeywell PC45 Series
Posted by Thermal Printer Supplies on Oct 14th 2025
When it comes to 4-inch desktop label printing, two of the most recognized names in the game are Zebra and Honeywell. The Zebra ZD420/ZD421 family and Honeywell PC45d/PC45t models represent the latest generation of thermal desktop printers that balance compact design, connectivity, and enterprise-ready performance.
This article dives deep into how these printers stack up across ten key categories — from media compatibility and speed to connectivity, accessories, durability, and long-term support — to determine who truly comes out on top.

Zebra ZD420 / ZD421 Printer Overview
The Zebra ZD420 (and its successor, the ZD421) is designed as a high-performance 4-inch desktop printer built for maximum flexibility, ease of use, and long-term serviceability. It replaces Zebra’s long-running GK420 series, offering faster print speeds, enhanced connectivity, and improved management capabilities through Link-OS and Zebra Print DNA.
The ZD420 is available in both direct thermal (DT) and thermal transfer (TT) versions, allowing users to choose between no-ribbon simplicity or long-lasting, durable printed output. One of the most distinctive features is the ribbon cartridge system—it loads only one way, eliminating ribbon setup errors and reducing downtime. The printer also features a movable media sensor, supporting a wide range of label and tag materials.
Connectivity options are extensive: USB 2.0, USB host, optional serial and Ethernet ports, plus dual wireless radio capability (Wi-Fi 802.11ac and Bluetooth 4.1 with MFi certification). NFC “Print Touch” simplifies mobile pairing and setup. DPI options include 203 dpi standard and 300 dpi (factory or field-upgradeable). Print speeds reach up to 6 inches per second (ips) at 203 dpi and around 4 ips at 300 dpi.
Zebra’s design focus is usability. The clamshell design simplifies media loading, while color-coded cues help users easily identify components they can touch or replace. Optional models include the ZD420-HC healthcare version, built with disinfectant-ready plastics and sealed buttons for hospitals and labs.

Honeywell PC45d / PC45t Printer Overview
The Honeywell PC45 Series (including the PC45d direct thermal and PC45t thermal transfer models) represents Honeywell’s next-generation desktop printer platform, following its popular PC43 and E-Class lines. The PC45 is built around Honeywell’s Printer Edge platform, which offers centralized configuration, firmware updates, and remote diagnostics across large fleets of devices.
Both PC45d and PC45t offer flexible media handling, supporting widths from roughly 15 mm (0.59") to 118 mm (4.65"). The PC45t version supports ribbons for thermal transfer printing, while the PC45d is optimized for direct thermal labels. The series also supports both 203 dpi and 300 dpi resolutions, with maximum print speeds up to 8 ips—making it one of the faster desktop printers in its class.
Connectivity is a strong suit: standard interfaces include USB 2.0 (device + host) and Ethernet 10/100, with options for Wi-Fi 802.11ac and Bluetooth Low Energy (BLE). A large color touchscreen interface simplifies local configuration and diagnostics, giving the PC45 a modern and user-friendly edge.
Honeywell also offers a broad range of accessories and add-ons, including a cutter module, peel-and-present mechanism, media low sensor, RFID encoder, and external media holders. The printer supports multiple command languages—Fingerprint, Direct Protocol, Intermec IPL, ZSim2 (ZPL II), and DPL—for seamless integration into existing systems.
Media CompatibilityBoth Zebra and Honeywell cover their bases when it comes to printing methods and label flexibility. The ZD420/ZD421 supports both direct thermal and thermal transfer printing, with easy media swapping and a movable sensor that adapts to different label widths and gap styles. Its ribbon cartridge system is especially appealing for users who frequently switch rolls or need foolproof media changes. The Honeywell PC45d/PC45t also supports both DT and TT configurations, though each variant is fixed at purchase. Its adjustable sensors and wide 118 mm media path accommodate a large variety of label types. Honeywell’s broader maximum width gives it a slight edge for users printing larger labels, but Zebra’s cartridge system is more user-friendly. Verdict: Zebra wins on ease of use, Honeywell wins on width and modular flexibility. |
Print Speed and DPIZebra’s top print speed is 6 ips at 203 dpi and 4 ips at 300 dpi, which is perfectly adequate for most medium-volume label applications. Honeywell’s PC45 raises the bar with speeds up to 8 ips, making it the faster option when print throughput is critical. Both brands offer 203 and 300 dpi configurations, ensuring crisp barcode and text printing. Verdict: Honeywell takes the performance crown for raw print speed. |
Connectivity and CommunicationThe ZD420/ZD421 is highly configurable: USB 2.0 and USB Host are standard, with optional serial and Ethernet modules. Wireless options include Wi-Fi 802.11ac and Bluetooth 4.1 (MFi certified), providing reliable connectivity for enterprise environments and iOS devices. The PC45 series matches those features with USB host/device, Ethernet, Wi-Fi 802.11ac, and Bluetooth Low Energy. The key differentiator is its color touchscreen and modern embedded networking features, which make configuration and diagnostics easier directly from the printer. Verdict: Draw. Zebra offers strong ecosystem integration with Link-OS, while Honeywell’s interface and Printer Edge management add sophistication. |
Acquisition CostPricing varies by configuration, but in general:
Zebra typically carries the lower acquisition cost, making it more budget-friendly for small to mid-sized businesses. Verdict: Zebra wins for affordability. |
Accessories and Add-OnsZebra offers peelers, cutters, external rewinders, and mounting kits. The accessory ecosystem is extensive and benefits from Zebra’s wide distribution network. Honeywell’s PC45 accessory portfolio is even more comprehensive, including a cutter, peel/present mechanism, RFID module, media low sensor, and optional cellular modem. This flexibility makes it suitable for specialized or high-integration environments. Verdict: Honeywell wins for accessory variety. |
RFID OptionZebra’s ZD420 series does not include a native RFID model—RFID support is reserved for higher-end Zebra printers like the ZD611R or ZT400 series. Honeywell does offer an optional UHF RFID encoder for the PC45 series, giving it a clear advantage for organizations transitioning to RFID-based labeling or asset tracking. Verdict: Honeywell wins for RFID capability. |
Post-Sale Support and ServiceabilityZebra dominates the market for spare parts, repair centers, and long-term availability. Its Link-OS ecosystem provides seamless firmware updates, health checks, and centralized management across large deployments. Honeywell’s Printer Edge platform is strong as well, offering cloud-based management and diagnostics, but Zebra’s global scale gives it a broader service advantage and more readily available replacement parts. Verdict: Zebra wins for worldwide service support. |
WarrantyBoth printers carry a 2-year manufacturer warranty. Printheads and platen rollers are covered under standard consumable warranties from each brand. Verdict: Tie. |
Durability and ReliabilityZebra’s ZD420/ZD421 is a proven, field-tested platform with a long track record of reliability. It’s well-known for its intuitive design and consistent performance in warehouse, healthcare, and retail settings. The Honeywell PC45 is newer but built with industrial-grade components and modern electronics. While it doesn’t yet have the same market tenure, early feedback has been positive, especially regarding its solid build and print consistency. Verdict: Zebra wins for proven longevity; Honeywell’s design is promising but newer. |
Software Compatibility and IntegrationZebra’s compatibility with ZPL, EPL, and Link-OS tools (including Zebra Setup Utilities and Printer Setup for iOS/Android) make it an easy fit in existing Zebra environments. It also integrates seamlessly with major ERP and labeling platforms such as BarTender and Loftware. Honeywell counters with multi-language support (FP, DP, IPL, ZSim2, DPL) for smooth integration into mixed fleets, plus the Printer Edge cloud management suite. Both brands are well-supported in Windows, Android, and iOS environments. |
Desktop Printer Battle: Final Verdict
In a pure head-to-head:
Ease of Use & Reliability: Zebra ZD420/ZD421 wins
Speed & Performance: Honeywell PC45 wins
Connectivity & Software: Draw
Accessories & RFID Options: Honeywell PC45 wins
Support & Availability: Zebra wins
Overall Value: Zebra wins
If your priority is simplicity, proven performance, and lower total cost of ownership, the Zebra ZD420/ZD421 is the best overall choice.
If your focus is on speed, flexibility, RFID, and advanced integration features, the Honeywell PC45d/PC45t might be the better fit — particularly in higher-volume or enterprise environments already standardized on Honeywell platforms.

Overall Winner: Zebra ZD420/ZD421
— slightly ahead on reliability, affordability, and long-term ecosystem strength.
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